Dr. Stephen Phinney: Are there benefits of fasting, including autophagy and apoptosis?


these are hot hot buzzwords right now in
the research community there’s a lot of research been done with basically animal
models and what we what people talk about autophagy and apoptosis is
basically changing either you know regenerating cells from aging cells
regenerating with with yeah it’s good plate replacement cells and also the
cleaning system a cleaning system but also cleaning up internal cellular
machinery particularly involving things called mitochondria and mitochondria are
those little furnaces inside cells that actually do the oxidative energy
generation that’s where oxygen is consumed along with either fat or
carbohydrate to replace the high energy phosphate ATP and creatine phosphate and
so that machinery constantly has to be repaired and there was evidence that
periods of fasting can can enhance that process there’s been less research with
well formulated ketogenic diets done long enough to actually look at that and
again the turnover of cells and the turnover of mitochondria that is how
frequently replaced is measured in weeks or months not in a day or two and so
particularly for human you know to have human specific results it takes
rigorously done studies and there aren’t that many groups who have been able to
sustain ketogenic diets long enough to really look at that and again stay tuned
because that’s an area where dr. Bullock and his team are on the forefront of
doing that research yeah I think I’m certainly not an expert in this area but
I think Otto Fei Jie can be stimulated by reduced insulin and increased
glucagon inhibition of mTOR so it would I know a lot of the research is in
fasting and ketogenic diets tend to mimic that
from a metabolism standpoint in a lot of ways so I would assume that you would be
able to get some similar benefits out of doing it for a long time

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Reader Comments

  1. JoelaniFit

    I believe it is our duty as keto people to inspire others to change the deep ideas in their minds that fat is bad and carbs are good

  2. Murat Rustu Akman

    I have a question for Dr Phinney. For a lean healthy individual who is on a ketogenic diet for a year, is it beneficial or disadvantageous to be also on a partial day fasting everyday (skipping breakfast and having luch and dinner everyday)?

  3. elliott debell

    It’s like he’s never seen Valter longo’s and Jason fungs research. I don’t think citing old studies from ww2 disproves Valter’s work. we have new research backed by solid data that contradicts what phinney is saying. I can only assume phinney is barking up the wrong tree 🌲 he also says fasting efficacy has not been proven by long term studies… nor has the ketogenic. There are no ketogenic blue zones for study. A well balance pescatarian diet has far more data on its side. People Plato on the ketegenic diet also.

  4. Peter

    On autophagy, see Rhonda Patrick's 2017 excellent talk with Prof Guido Kroemer – https://www.youtube.com/watch?v=Gm626MgpveI&t=804s. Take notes. As a layman following the research, it seems that periodically driving the nutrient signals to very low levels using something like Valter Longo's FMD makes sense as does a more chronic approach using time restricted eating (Panda) all on top of a diet which eliminates sugars, simple carbs, and excess protein. My own testing shows that Ketones routinely stay subclinical (but measurable) and often go into the low clinical range just on a quality diet (whole food vegan) in combination with a 16/8 to 20/4 TRE regime. Using increased BHB as a marker suggests the metabolic changes needed to increase basal autophagy (e.g. lowering insulin, mTOR) are moving in the right direction. If basal autophagy does not adapt and reset to prior levels, then long term TRE in which BHB hovers around clinical levels should have profound positive effects just on the basis of more effective autophagy in comparison to a standard westerner who suppresses autophagy eating crap all day.

  5. Bushbuddy Platypus

    I saw a medical researcher explain that autophagy can't happen in the presence of proteins. So only pure fat keto is going to get you there?

  6. KJ Always

    I think I am better off losing weight real slowly at the pace of the elasticity of my skin (2 pounds a week/ 8 pounds a month). It is more simple for me. Plus, it gives more time to turn a diet into a lifestyle to live with.

  7. tyanite1

    We have anecdotal information on extended fasting being curative for conditions that have not responded to any other treatments. I wonder how we could study autophagy, apoptosis and the stimulation of stem cells that take place during extended fasting, specifically when it comes to how I extended fasting might transform diseased lungs, liver, heart, kidneys and other vital organs.

  8. Katherine George

    I found autophagy in the bible Matthew 9:17:

    14 Then John’s disciples came and asked him, “How is it that we and the Pharisees fast but your disciples do not fast?”

    15 Jesus answered, “How can the guests of the bridegroom mourn while he is still with them. The time will come when the bridegroom will be taken from them; then they will fast.

    16 “No one sews a patch of unshrunk cloth on an old garment, for the patch will pull away from the garment, making the tear worse. 17 Neither do people pour new wine into old wineskins. If they do, the skins will burst; the wine will run out and the wineskins will be ruined. No, they pour new wine into new wineskins, and both are preserved.”

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